A home safe can weigh anywhere from 200 to over 1,000 pounds, and the biggest danger is not dropping it, it is tipping it onto its back where the weight concentrates on a single edge and can crack a floor or a foot. Professional safe movers exist for a reason.
Pro tip: Call two or three local safe movers for quotes; the cost is almost always worth it compared to the risk of a floor repair or an injury claim.
Watch out: Tipping a filled safe onto its back can crack the floor beneath it or damage the internal locking mechanism, sometimes permanently jamming the door.